The effect of synaptic short-term plasticity on granule cell activity in the dentate gyrus microcircuit

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What role does synaptic short-term plasticity play for information processing in the dentate gyrus?

Dentate gyrus granule cells - the first relay cells of the trisynaptic hippocampal circuit - receive excitatory input from the entorhinal cortex. We aim to investigate the role of synaptic short-term plasticity for the integration of the excitatory input.

Specifically, we will analyze if altering short-term plasticity affects specific properties of granule cells such as sparse firing. This work will help us understand how input from the entorhinal cortex is conveyed to and processed in the dentate gyrus by selectively recruiting specific granule cells into active ensembles.
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*Principal investigators of other projects within the CRC