A02

The effect of synaptic short-term plasticity on granule cell activity in the dentate gyrus microcircuit

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What role does synaptic short-term plasticity play for information processing in the dentate gyrus?

Dentate gyrus granule cells - the first relay cells of the trisynaptic hippocampal circuit - receive excitatory input from the entorhinal cortex. We aim to investigate the role of synaptic short-term plasticity for the integration of the excitatory input.

Specifically, we will analyze if altering short-term plasticity affects specific properties of granule cells such as sparse firing. This work will help us understand how input from the entorhinal cortex is conveyed to and processed in the dentate gyrus by selectively recruiting specific granule cells into active ensembles.
Publications
Khodosevich K, Lazarini F, von Engelhardt J, Kaneko H, Lledo PM, Monyer H* (2013) Connective Tissue Growth Factor Regulates Interneuron Survival and Information Processing in the Olfactory Bulb. Neuron. 79:1136-51.

von Engelhardt J, Khrulev S, Eliava M, Wahlster S, Monyer H* (2011) 5-HT(3A) receptor-bearing white matter interstitial GABAergic interneurons are functionally integrated into cortical and subcortical networks. J Neurosci 31:16844-16854.

von Engelhardt J, Mack V, Sprengel R*, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H* (2010) CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science 327:1518-1522.

Korotkova T, Fuchs EC, Ponomarenko A, von Engelhardt J, Monyer H* (2010) NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron 68:557-569.

von Engelhardt J, Doganci B, Jensen V, Hvalby O, Gongrich C, Taylor A, Barkus C, Sanderson DJ, Rawlins JN, Seeburg PH, Bannerman DM, Monyer H* (2008) Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron 60:846-860.

Inta D, Alfonso J, von Engelhardt J, Kreuzberg MM, Meyer AH, van Hooft JA, Monyer H* (2008) Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proceedings of the National Academy of Sciences of the United States of America 105:20994-20999.

von Engelhardt J, Eliava M, Meyer AH, Rozov A, Monyer H* (2007) Functional characterization of intrinsic cholinergic interneurons in the cortex. J Neurosci 27:5633-5642.

*Principal investigators of other projects within the CRC