Structural and functional diversity of the axon initial segment of principal neurons in hippocampal ensembles
Action potentials (APs) are usually initiated in the axon initial segment (AIS), a highly specialized neuronal compartment. Recent evidence suggests that location and length of the AIS is a variable and independent determinant of neuronal excitability. Recently, we have found that the AIS branches off from basal dendrites rather than from the soma in about 50% of CA1 pyramidal cells. Our preliminary data show that such axon-carrying dendrites (AcD) are privileged sites for synaptic excitation, supporting facilitated action potential generation.
Pfeiffer T, Draguhn A*, Reichinnek S, Both M (2014) Optimized temporally deconvolved Ca2+ imaging allows identification of spatiotemporal activity patterns of CA1 hippocampal ensembles. NeuroImage pii:S1053-8119(14)00177-3
Gutzmann A, Ergül E, Grossmann R, Schultz C, Wahle P, Engelhardt M (2014) A period of structural plasticity at the axon initial segment in developing visual cortex. Front Neuroanat 8:11.
Zylla MM, Zhang XM, Reichinnek S, Draguhn A*, Both M (2013) Cholinergic plasticity of oscillating neuronal assemblies in mouse hippocampal slices. PLoS One 8:e80718.
Reichinnek S, von Kameke A, Hagenston AM, Freitag E, Roth FC, Bading H*, Hasan MT, Draguhn A*, Both M (2012) Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro. NeuroImage 60:139-152.
Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M§, Draguhn A*§ (2011) Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proc Natl Acad Sci U S A 108:E607-616. § equal contribution
Reichinnek S, Künsting T, Draguhn A*, Both M (2010) Field Potential Signature of Distinct Multicellular Activity Patterns in the Mouse Hippocampus. J Neurosci 30:15441-15449.
Winkels R, Jedlicka P, Weise FK, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of betaIV-spectrin mutant mice in vivo. Hippocampus 7:677- 686.
Jedlicka P, Schwarzacher SW, Winkels R, Kienzler F, Frotscher M, Bramham CR, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus 19:130-140.
Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C. (2008) Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier. Neuropathol Appl Neurobiol. 34:357-365.
Both M, Bähner F, von Bohlen und Halbach O, Draguhn A* (2008) Propagation of specific network patterns through the mouse hippocampus. Hippocampus 18:899-908.
Bas Orth C, Schultz C, Müller CM, Frotscher M, Deller T (2007) Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice. J Comp Neurol 504:441-449.
*Principal investigators of other projects within the CRC