Identified neuronal ensembles subserving spatial coding in the medial entorhinal cortex
The activity of spatially-tuned excitatory neurons in the hippocampal-entorhinal formation – i.e. place cells in the hippocampus and grid cells in the medial entorhinal cortex (mEC) – is a prerequisite for the generation of spatial maps. The mechanisms underlying the generation of spatial representations are not known, but are likely to depend on the interaction between excitatory and inhibitory neurons within local microcircuits in the hippocampus and mEC, as well as the interaction between these two brain regions.
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*Principal investigators of other projects within the CRC