Neuronal ensembles and metabolic homeostasis during gamma oscillations in the hippocampal CA3 network
Gamma oscillations (30-100 Hz) occur in most regions of the cortex, including the hippocampus. They have been implicated in higher cognitive functions such as sensory perception, selective attention and memory formation. The patterned neuronal activity during gamma oscillations goes along with strongly increased energy expenditure. However, the relationship between activation of pyramidal cell ensembles during gamma oscillations and metabolic homeostasis is largely unknown.
Liotta A, Rösner J, Huchzermeyer C, Wojtowicz A, Kann O, Schmitz D, Heinemann U, Kovács R (2012) Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse. J Cereb Blood Flow Metab 32:2076-83.
Kann O, Taubenberger N, Huchzermeyer C, Papageorgiou IE, Benninger F, Heinemann U, Kovács R (2012) Muscarinic receptor activation determines the effects of store-operated Ca(2+)-entry on excitability and energy metabolism in pyramidal neurons. Cell Calcium 51:40-50.
Kann O, Huchzermeyer C, Kovács R, Wirtz S, Schuelke M (2011) Gamma oscillations in the
hippocampus require high complex I gene expression and strong functional performance of mitochondria. Brain 134:345-358.
Huchzermeyer C, Albus K, Gabriel HJ, Otáhal J, Taubenberger N, Heinemann U, Kovács R, Kann O (2008) Gamma oscillations and spontaneous network activity in the hippocampus are highly sensitive to decreases in pO2 and concomitant changes in mitochondrial redox state. J Neurosci 28:1153-1162.
Kann O, Kovács R, Njunting M, Behrens CJ, Otáhal J, Lehmann TN, Gabriel S, Heinemann U 2005) Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. Brain 128:2396-2407.
Kann O, Schuchmann S, Buchheim K, Heinemann U (2003) Coupling of neuronal activity and mitochondrial metabolism as revealed by NAD(P)H fluorescence signals in organotypic hippocampal slice cultures of the rat. Neuroscience 119:87-100.
*Principal investigators of other projects within the CRC