Role of Dnmt3a2 in the establishment and stability of experience-dependent cell ensembles
The hippocampus is thought to play a critical role in the formation and consolidation of new spatial memories via the establishment and stabilisation of new cell ensembles (also called assemblies). The
molecular pathways that regulate this process are still largely unknown.
Allen K, Rawlins NP, Bannerman DM, Csicsvari J. (2012) Hippocampal place cells can encode multiple trial-dependent features through rate remapping. J Neurosci 32: 14752-14766.
Oliveira AMM, Hemstedt TJ, Bading H* (2012) Rescue of aging-associated decline in Dnmt3a2 restores cognitive abilities. Nature Neurosci 15: 1111-1113.
Allen K, Fuchs EC, Jaschonek H, Bannerman DM, Monyer H* (2011) Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory. J Neurosci 31:6542-6552.
Oliveira AMM, Estevez MA, Hawk JD, Grimes S, Brindle PK, Abel T (2011) Subregion-specif- ic p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem 18:161-169.
Oliveira AMM, Hawk JD, Abel T and Havekes R (2010) Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learn Mem 17:155-160.
Huxter J, Senior T, Allen K, O’Neill J, Csicsvari J (2008) Theta phase-specific codes for two-di- mensional position, trajectory, and heading in the hippocampus. Nature Neurosci 11:587- 594.
O’Neill J, Huxter J, Senior T, Allen K, Csicsvari J (2008) Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neurosci 11:209-215.
Oliveira AMM, Wood MA, McDonough C, Abel T (2007) Transgenic mice expressing a truncated form of p300 exhibit memory deficits. Learn Mem 14:564-572.
Wood MA, Attner M, Oliveira AMM, Brindle PK, Abel T. (2006) A transcription factor-binding do- main of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem 13:609-617.
*Principal investigators of other projects within the CRC