C04

Modulation of odor-entrained ensembles by phasic dopamine in the olfactory striatum

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Phasic dopamine release mediates the ‘salience’ of environmental stimuli whereby one stimulus becomes dominant over competing other inputs.

To obtain a better understanding of the mechanisms of stimulus selection, we propose here to examine the cellular processes by which phasic dopamine modulates ventral striatal odour-activated cellular ensembles with slice and in vivo tetrode recordings.

Particularly, we will test whether weakly and strongly responding neurons to odours display similar plasticity induced by midbrain phasic dopamine and dopamine’s recently discovered direct control of striatal cholinergic tone, hoping to further our understanding of these clinically relevant transmitters.
Publications
Kelsch W, Li Z, Eliava M, Goengrich C, Monyer H* (2012) GluN2B-containing NMDA receptors promote wiring of adult-born neurons into MOB circuits. J Neurosci 32:12603-11.

Kelsch W, Sim S, Lois C (2012) Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats. J Comp Neurol 520:1327-38.

Lin CW, Sim S, Ainsworth A, Okada M, Kelsch W, Lois C (2010) Genetically increased cell- intrinsic excitability enhances neuronal integration into adult brain circuits. Neuron 65:32- 9.

Kelsch W, Lin CW, Mosley CP, Lois C (2009) A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis. J Neurosci. 29:11852-8.

Kelsch W, Lin CW, Lois C (2008) Sequential development of synapses in dendritic domains during adult neurogenesis. Proc Natl Acad Sci U S A 105(43):16803-8.

*Principal investigators of other projects within the CRC